Lifespan and reproduction in brain-specific miR-29-knockdown mouse
نویسندگان
چکیده
منابع مشابه
Sex-specific effects of protein and carbohydrate intake on reproduction but not lifespan in Drosophila melanogaster
Modest dietary restriction extends lifespan (LS) in a diverse range of taxa and typically has a larger effect in females than males. Traditionally, this has been attributed to a stronger trade-off between LS and reproduction in females than in males that is mediated by the intake of calories. Recent studies, however, suggest that it is the intake of specific nutrients that extends LS and mediat...
متن کاملThe lifespan-reproduction trade-off under dietary restriction is sex-specific and context-dependent.
Adult dietary restriction (DR) extends lifespan, but the mechanisms that underlie this effect are not well understood. Many DR studies have demonstrated that lifespan extension tends to be accompanied by a reduction in female fecundity - a correlation widely interpreted as evidence that DR triggers an adaptive re - allocation of resources from reproduction to somatic maintenance. Yet, recent ev...
متن کاملMiR-29/Hsp47 in ECM network
Cancer development and progression require extensive reorganization of extracellular matrix [1, 2]. ECM is a complex mixture of structural proteins, glycoproteins, and proteoglycans, which provide not only essential physical scaffolds to maintain tissues structure but also various biochemical signals to modulate cellular function. Altering the fine balance of ECM signal is sufficient in the lon...
متن کاملDecreased miR-29 suppresses myogenesis in CKD.
The mechanisms underlying the muscle wasting that accompanies CKD are not well understood. Animal models suggest that impaired differentiation of muscle progenitor cells may contribute. Expression of the myogenesis-suppressing transcription factor Ying Yang-1 increases in muscle of animals with CKD, but the mechanism underlying this increased expression is unknown. Here, we examined a profile o...
متن کاملSex-Specific Fitness Effects of Nutrient Intake on Reproduction and Lifespan
Diet affects both lifespan and reproduction [1-9], leading to the prediction that the contrasting reproductive strategies of the sexes should result in sex-specific effects of nutrition on fitness and longevity [6, 10] and favor different patterns of nutrient intake in males and females. However, males and females share most of their genome and intralocus sexual conflict may prevent sex-specifi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2016
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2016.02.055